Category Hematology

Flowcytometry Basics

The measurement or quantification of cells suspended in a fluid phase is performed using flow cytometry. Fluorochrome-coupled antibodies specific for a certain cellular marker are used to label the cells. The fluidics chamber enables that cell travel via a laser…

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Lupus Erythematosus Cell

INTRODUCTION Hargraves et al., identified the LE cell phenomena in bone marrow in 1948. Lupus erythromatosus is an autoimmune disease in which autoantibodies attack cell nuclei components. In lupus erythromatosus, antibodies such as LE factor, antinuclear antibodies (ANA), anti double…

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D-Dimer

During hemostasis, coagulation system development of fibrin clots as a reaction to vascular injury is regulated by the fibrinolytic system breakup of the clot. D- Dimers are one of several fragments formed when plasmin, an enzyme that is activated by…

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Activated Partial Thromboplastin Time (APTT)

The activated partial thromboplastin time (APTT or aPTT) is a coagulation test used to evaluate low-dose heparin therapy and test for the function of hemostasis’ intrinsic and normal pathway. The reagent used to perform the APTT is partial thromboplastin, which…

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Immune (Idiopathic) Thrombocytopenic Purpura

Primary immune thrombocytopenia (ITP), commonly known as idiopathic thrombocytopenic purpura, is an inflammatory bleeding disorder that affects both adults and infants. Until quite recently, it was considered an autoantibody disorder in which the reticuloendothelial system prematurely removed platelets, which were…

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Pelger-Huët Anomaly

Pelger-Huët anomaly (PHA), also known as true or congenital PHA, is an autosomal dominant condition marked by reduced nuclear segmentation (bilobed, unilobed) and a distinctive coarse chromatin clumping pattern that can involve any leukocyte, while morphologic differences are more noticeable…

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