alpha-Thalassemia

Thalassemia is a group of genetic conditions wherein defects in one or more globin genes generate reduced or insufficient production of the associated globin chains. Patients with minor genetic abnormalities are usually asymptomatic. Patients with more severe abnormalities have symptoms caused by one or more of the following: low formation …

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Lupus Erythematosus Cell

Introduction Hargraves et al., identified the LE cell phenomena in bone marrow in 1948. Lupus erythromatosus is an autoimmune disease in which autoantibodies attack cell nuclei components. In lupus erythromatosus, antibodies such as LE factor, antinuclear antibodies (ANA), anti double stranded DNA (anti ds DNA), anti single stranded DNA, anti …

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D-Dimer

During hemostasis, coagulation system development of fibrin clots as a reaction to vascular injury is regulated by the fibrinolytic system breakup of the clot. D- Dimers are one of several fragments formed when plasmin, an enzyme that is activated by the fibrinolytic pathway, cleaves fibrin to break down clots. It …

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Immune (Idiopathic) Thrombocytopenic Purpura

Primary immune thrombocytopenia, commonly known as idiopathic thrombocytopenic purpura(ITP), is an inflammatory bleeding disorder that affects both adults and infants. It was previously thought to be an autoantibody condition in which the reticuloendothelial system prematurely destroyed platelets that had been opsonized with antiplatelet antibody. Recent studies have revealed that there …

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