Tissue Processing in Histopathology Laboratory

Tissue processing is a critical technique in histopathology that prepares tissue specimens for microscopic examination. Through this meticulous process, samples are preserved, allowing pathologists to examine cellular structures for the diagnosis of various diseases. Introduction What is Tissue Processing? Tissue processing in histopathology refers to the systematic procedure of preparing …

Read more

Platelet Neutralization Test

The Platelet Neutralization Test (PNT) plays a pivotal role in diagnosing blood disorders, especially those related to platelet function. This test is crucial in the diagnosis of conditions like Heparin-Induced Thrombocytopenia (HIT), Autoimmune Thrombocytopenic Purpura (ITP), and other platelet dysfunction disorders. By identifying antiplatelet antibodies, the PNT helps clinicians determine …

Read more

Magnesium Testing: Methods, Interpretation & Clinical Insights

Magnesium is a cofactor in over 600 enzymatic reactions, crucial for ATP production, DNA/RNA synthesis, ion transport, and neuromuscular signaling. Deficiency or excess can cause: Due to homeostatic buffering by intestinal absorption and renal excretion, serum magnesium can remain normal even when total body or tissue levels are low. Clinicians …

Read more

AMH Test: Principle, Procedure, and Clinical Significance

The Anti-Müllerian Hormone (AMH) test is an important diagnostic measurement in reproductive medicine, providing a cycle-independent measure of ovarian reserve, fertility potential, and endocrine health. Its stability (CV <5%) and strong correlation with antral follicle count (r=0.8–0.9) make it a preferred biomarker over FSH or estradiol for fertility assessment, PCOS …

Read more

Non Invasive Prenatal Testing: NIPT Explained

Non-Invasive Prenatal Testing (NIPT) has changed the way prenatal care is done. It provides expectant parents with important genetic information about their unborn child through a simple blood test. This innovative screening method analyzes small fragments of DNA from the fetus that are present in the mother’s blood to detect …

Read more

Craniofacial Disorders: Genes, Diagnosis, and Hope

Craniofacial disorders entail a wide spectrum of issues affecting the anatomy and development of the skull and face. These abnormalities, ranging from cleft lip and palate to craniosynostosis and Treacher-Collins syndrome, can have serious physical and mental consequences. Understanding the genetic links underlying craniofacial abnormalities is critical for proper diagnosis, …

Read more

Spinal muscular atrophy (SMA)

Spinal muscular atrophy (SMA) is a rare autosomal recessive neuromuscular disorder characterized by the loss of lower motor neurons (anterior horn cells) in the spinal cord and brainstem nuclei, resulting in progressive muscle weakening and atrophy. The severity and age at onset differ considerably. SMA was initially documented in the …

Read more