Immune (Idiopathic) Thrombocytopenic Purpura (ITP)

Primary immune thrombocytopenia, commonly known as idiopathic thrombocytopenic purpura(ITP), is an inflammatory bleeding disorder that affects both adults and infants. It was previously thought to be an autoantibody condition in which the reticuloendothelial system prematurely destroyed platelets that had been opsonized with antiplatelet antibody. Recent studies have revealed that there …

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Pelger-Huët Anomaly

Pelger-Huët anomaly (PHA), also known as true or congenital PHA, is an autosomal dominant condition marked by reduced nuclear segmentation (bilobed, unilobed) and a distinctive coarse chromatin clumping pattern that can involve any leukocyte, while morphologic differences are more noticeable in mature neutrophils. A mutation in the lamin β-receptor gene …

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